PHYSICOCHEMICAL PROPERTIES IN RELATION TO BIOLOGICAL ACTION
Physicochemical Properties refers to physical and chemical characteristics of a drug molecule that influence it's behaviour in biological systems. • These properties plays a crucial role in determining the drug's absorption, distribution, metabolism and excretion.
• It includes:
⑦Ionisation
②Solubility
3 Partition Coefficient
Hydrogen Bonding © Protein Binding ⑥Chelation
Bibisosterism
Optical Geometrical Isomerism.
IONISATION
BARBITURATES
Barbiturates are potent CNS depressants.
They are medicines that slow down brain or CNS activity.
They can be very strong and risky if not used carefully.
They are used to treat anxiety, sleep problems and siezures etc. They includes:
Barbital *
2 Phenobarbital
③Mephobarbital
Amobarbital
→ Butabarbital ⑥Pentobarbital
→ Secobarbital
MECHANISM OF ACTION
• Barbiturates are work by increasing the effect of GABA, a calming chemical of brain and slows down brain activity, helping
MML7 Including intermediate Filaments - Cytoskeleton structure and function.
Actin is the most abundant intracellular protein in a eukaryotic cell, some organisms may only have one gene. Humans have 6 actin genes that encode different isoforms. 4 α actin isoforms present in various muscle cells. β and γ actin isoforms in non-muscle cells. Differ in only 4-5 amino acids. Actin microfilaments. Monomer: G-actin (globular form) Polymer F-actin (filamentous form). Functions Local restructuring of...
Acting – Bringing script to life.
Playwright – Writes the play.
Representational style – Real-life acting, no eye contact.
Presentational style – Talks to audience.
Fourth wall – Invisible wall between actors/audience.
Character – Role played by actor.
Audition – Try out for a role.
Characterization – Building a character.
Subtext – Implied meaning under lines.
Historical – Real-life character.
Classical
1. what is IKS?
Indian Knowledge System (IKS) is the traditional knowledge developed in India over centuries in various fields.
It includes subjects like science, math, medicine, art, literature, and philosophy.
Great Indian scholars like Aryabhata and Sushruta contributed to global knowledge.
IKS promotes harmony with nature and sustainable living.
It also teaches values, ethics, and well-being through systems like Yoga and Vedanta
what is vedic corpus?
The Vedic corpus includes four
Marco Rios (920439696)
Threat Actors → The people/groups launching attacks. Mnemonic: “NO HIS” (Nation-State, Organized Crime, Hacktivists, Insiders, Script Kiddies)
| Actor Type | Motivation | Tactics |
|---|---|---|
| Nation-State (APT Groups) | Espionage, warfare | Advanced, persistent attacks |
| Organized Crime | Financial gain | Ransomware, phishing |
| Hacktivists | Social justice, ideology | Website defacement, data leaks |
| Insiders | Revenge, profit | Data |
Plant tissue culture is the technique of growing plant cells, tissues and organs in an artificial medium under aseptic conditions.The applications of plant tissue culture are as follows(a) Clonal multiplicationsTissue culture is a rapid and cheap method of multiplication Many agricultural and horticultural plants are multiplied by this method, which is also called micropropagation. Raising plants by this method has the following advantages.(i) Disease-free stocks can be prepared by this method.(