DM.COMPLICATIONS:Pathogenesis: Chronic hyperglycemia → AGEs, PKC activation, ↑ ROS, polyol pathway → endothelial dysfunction, basement membrane thickening, micro + macrovascular damage.Microvascular: Retinopathy: Non-proliferative (microaneurysms, hemorrhages, cotton-wool spots, macular edema); Proliferative (neovascularization → vitreous hemorrhage, retinal detachment).Tx: glycemic/BP control, anti-VEGF, laser.Nephropathy: GBM thickening, mesangial expansion, Kimmelstiel-Wilson nodules;
Maintenance is the activity of keeping machines, equipment, and systems in proper working condition so that they perform efficiently and safely throughout their service life.
Importance of maintenance:
Increases equipment life – Regular maintenance reduces wear and tear.
Improves reliability – Machines work smoothly with fewer breakdowns.
Ensures safety – Prevents accidents due to machine failure.
Reduces breakdown cost – Early detection avoids major repair
/// min array jumps
int minimumJumps(const vector<int>& a) {
int n = static_cast<int>(a.size());
if(n==1) return 0;
if(a[0]==0) return -1;
int jumps = 0;
int currentEnd = 0;
int farthest = 0;
for(int i=0;i<n-1;++i){
farthest = max(farthest,i + a[i]);
if(farthest<=i) return -1;
if(i==currentEnd){
++jumps;
currentEnd...
ORGANIZAÇÃO E EMPRESA
Organização
Uma organização é uma unidade social que agrega duas ou mais pessoas que trabalham de forma estruturada para atingir objetivos comuns.
Elementos essenciais:
Recursos humanos, Recursos materiais, Forma organizativa, Finalidade (objetivos)
Empresa
A empresa é um tipo específico de organização produtiva que integra recursos humanos e materiais com o objetivo de produzir bens ou serviços, assegurando a sua autossustentação e lucratividade.
Características
facto jurídico- qualquer acontecimento que produza efeitos juridicos, pode ser: voluntário(depende da vontade humana) ex: celebrar um contrato; involuntário(independente da vontade humana) ex: nascimento, morte, um desastre natural; ato juridico- ato humano voluntario, vontade humana consistente dirigida a produzir efeitos juridicos;teorias sobre o estado de natureza- jean-jaques rousseau: ser humano naturalmente bom, no e.n. viveria sozinho, livre e feliz, quand entra em sociedade é corrompido
The Solar System is our "cosmic neighborhood." It is a gravitationally bound system consisting of one star—the Sun—and every object that orbits it, either directly or indirectly. Formed about 4.6 billion years ago from a giant cloud of gas and dust, it has evolved into a complex arrangement of planets, moons, and smaller icy or rocky bodies.
1. The Center: The Sun -The Sun is the heart of the system. It is so massive that it contains 99.8% of the total mass of the entire solar system. Its powerful
β. Εσωτερική αναδιοργάνωση
Για την αποτελεσματικότερη διακυβέρνηση του κράτους επιδιώχθηκε μια εκτεταμένη διοικητική μεταρρύθμιση, η δημιουργία των θεμάτων. Τα θέματα αρχικά ήταν στρατιωτικές μονάδες, μετακινούμενες ανά την επικράτεια. Όταν οι μονάδες αυτές απέκτησαν μόνιμη
The Geological Time Scale (GTS) is the "calendar" for Earth's 4.54-billion-year history. It organizes the vast expanse of deep time into nested units based on major geological events (like mountain building) and biological shifts (like mass extinctions).
Scientists use chronostratigraphy (stacking rock layers) and geochronology (radiometric dating) to refine these dates.
Hierarchy of Time Divisions
Geological time is divided into units of varying lengths, from the massive Eons to the more specific